Bhrathkanth Reddy M¹, Ranjith kumar P², P.L John Israel³

¹Postgraduate student, ²Assistant Professor ,³Professor and Head, Department of General Medicine, Prathima Institute of Medical Sciences, Nagunur, Karimnagar, Telangana, India.

Address for correspondence: Dr. Bharathkanth Reddy M, Postgraduate Student, Department of General Medicine, Prathima Institute of Medical Sciences,Karimnagar,Telangana,India.

Email: bharathkanth24@gmail.com

Summary: Central nervous system(CNS) demyelinative diseases are mainly Multiple Sclerosis, Acute Disseminated Encephalomyelitis (ADEM), Acute hemorrhagic Leucoencephalitis (AHL). Multiple Sclerosis is the most common. A clinically isolated syndrome is the result of a single episode of demyelination in one area of the central nervous system (a monofocal episode) or several areas of the central nervous system (a multifocal episode) which lasts for at least 24 hours. Among the people who are diagnosed with Multiple Sclerosis(MS), 85% experience an initial onset of symptoms or a first attack that is referred to as a clinically isolated syndrome (CIS). Here we are reporting different cases of central nervous system demyelinating diseases presented to Prathima Institute of Medical Sciences(PIMS) with various manifestations. Magnetic Resonance Imaging(MRI) findings have been discussed.

Keywords : Clinically Isolated Syndrome, Multiple Sclerosis, ADEM, AHL, MRI.