Association of serum Magnesium levels with renal function in patients with diabetes mellitus type 2. A cross sectional study in rural population of North Telangana

Year : 2018 | Volume : 6 | Issue : 3 Page : 37-39

Kishan Reddy H¹, Venugopal B².

¹Associate Professor,²Assistant Professor, Department of Biochemistry, Prathima Institute of Medical Sciences,Nagunur, Karimnagar,Telangana,India.
Address for correspondence: Address for Correspondence: Venugopal B, Assistant Professor,Department of Biochemistry, Prathima Institute of Medical Sciences,Nagunur, Karimnagar,Telangana,India.

Email: boddula9586@gmail.com

Abstract

Introduction : Diabetes mellitus is one of the most common metabolic disorder and leading cause of death and disability in the world. Magnesium deficiency can lead to development of diabetic complications such as nephropathy, retinopathy, thrombosis and hypertension. This is a cross sectional study designed to determine whether there is any association between serum magnesium concentration [Mg2+] and the rate of renal function deterioration in patients with diabetes mellitus type 2 (DM2).

Materials & Methods: A cross sectional study was done in randomly chosen 50 Type 2 diabetic patients without renal dysfunction,50 diabetic with renal dysfunction of age between 40 and 60 years, 50 non diabetic controls with age and sex matched attending our institute during November-February-2018 were included. All patients and controls underwent thorough clinical examination and estimation of serum Magnesium, FBS, PPBS, hemoglobin A(1C), urinary albumin creatine ratio(UACR), as well as history of hypertension and pharmacy profiles were retrieved.

Results: The mean serum magnesium levels among Type 2 DM with renal dysfunction , Type 2 DM without renal dysfunction and healthy controls were 0.795±0.199mg/dl, 1.319±0.103mg/dl, 2.33±0.28mg/dl respectively.

Conclusion: There was a significant reduction in serum Magnesium [Mg] levels in diabetics compared to the controls. Lower “Mg” is associated with a faster renal function deterioration rate in Type 2 DM patients.

Keywords :Diabetes mellitus(DM) , Hypomagnesaemia, urinary albumin Creatinine ratio(UACR), Magnesium(Mg)