Background:Necrotising fasciitis(NF) is one of the most fulminant infection of skin and soft tissue. It is a fatal rapidly progressing disease causing Multi organ Dysfunction syndrome (MODS), septic shock & death if not identified early & treated accordingly. The aim is to study risk factors associated with NF and predictors of outcome.

Settings & design: Prospective observational study in a single tertiary care center.

Materials and Methods:Prospective analysis of patients with NF from March 2018 – August 2019 was done. The known risk factors were studied.

Results: A Total 120 patients were reviewed. Out of which 81 (67.5%) were males and 39 (32.5%) were females. The mortality rate in our study was 14.16%. It was significantly high in patients with CRF (p 0.045), HIV (p <0.001), Diabetes with other risk factors (p 0.003),BSA > 10% (p <0.01), Type 3 culture (0.027),LRINEC score >6 (p 0.015).

Conclusion:NF in patients with known risk factors progresses rapidly, so aggressive treatment should be given at the earliest. Early identification & prompt intervention is the key for better survival outcome in NF.