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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="Original Article">
  <front>
    <journal-meta id="journal-meta-90af7362ed954637ae086ee2df39f0fc">
      <journal-id journal-id-type="nlm-ta">Prathima Institute of Medical Sciences</journal-id>
      <journal-id journal-id-type="publisher-id">Prathima Institute of Medical Sciences</journal-id>
      <journal-id journal-id-type="journal_submission_guidelines">https://www.pimr.org.in/instructions.php</journal-id>
      <journal-title-group>
        <journal-title>Perspectives in Medical Research</journal-title>
      </journal-title-group>
      <issn publication-format="electronic">2348-229X</issn>
      <issn publication-format="print">2348-1447</issn>
    </journal-meta>
    <article-meta id="article-meta-d428dd98300544babf7859cef0aefc02">
      <article-id pub-id-type="publisher-id">12</article-id>
      <article-id pub-id-type="doi">10.47799/pimr.0903.12</article-id>
      <article-categories>
        <subj-group>
          <subject>Original Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title id="article-title-85c09aedffda48e48b6be1f4fba42114">
          <bold id="strong-3f04d2616fd94d27aa531a0cbcdc8f1c">Randomized Controlled Trial to Evaluate the Efficacy of Intrathecal Dexmedetomidine to Low dose hyperbaric 0.5% Bupivacaine in Elective Lower Segment Caesarean Section</bold>
        </article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name id="name-503a6ad33d654cb89224abd9bdfc81b9">
            <surname>Borse</surname>
            <given-names>Yogesh</given-names>
          </name>
          <email>drymborse@gmail.com</email>
          <xref id="xref-19e66dc0154741d3bef14ebf3168e8cf" rid="aff-f5c509dfdcb24e4db7b6bf2d904b76a9" ref-type="aff">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name id="name-88851cacdb2e4b8eaf122e696a0f771d">
            <surname>Patil</surname>
            <given-names>Anil</given-names>
          </name>
          <xref id="x-f4507df736c8" rid="a-f394dd7850e4" ref-type="aff">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name id="n-a5296d84e3dc">
            <surname>Thorat</surname>
            <given-names>Sandip</given-names>
          </name>
          <xref id="x-5c5a21b2f4dc" rid="a-b0a5f12cd633" ref-type="aff">3</xref>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name id="n-c5c4d5476649">
            <surname>Subhedar</surname>
            <given-names>Rajesh</given-names>
          </name>
          <xref id="x-a6645fdcea6a" rid="a-6635107bbe9b" ref-type="aff">4</xref>
        </contrib>
        <aff id="aff-f5c509dfdcb24e4db7b6bf2d904b76a9">
          <institution>Department of Anesthesiology , Shri Bhausaheb Hire Government Medical College</institution>
          <addr-line>Dhule</addr-line>
        </aff>
        <aff id="a-f394dd7850e4">
          <institution>Department of Anesthesiology, Government Medical College</institution>
          <addr-line>Jalgaon</addr-line>
        </aff>
        <aff id="a-b0a5f12cd633">
          <institution>Department of Anesthesiology, Shri Bhausaheb Hire Government Medical College</institution>
          <addr-line>Dhule</addr-line>
        </aff>
        <aff id="a-6635107bbe9b">
          <institution>Department of Anesthesiology, Shri Bhausaheb Hire Government Medical College</institution>
          <addr-line>Dhule, Maharashtra</addr-line>
        </aff>
      </contrib-group>
      <pub-date date-type="pub">
        <day>6</day>
        <month>1</month>
        <year>2022</year>
      </pub-date>
      <volume>9</volume>
      <issue>3</issue>
      <fpage>48</fpage>
      <lpage>53</lpage>
      <history>
        <date date-type="received">
          <day>6</day>
          <month>10</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>23</day>
          <month>10</month>
          <year>2021</year>
        </date>
        <date date-type="rev-recd">
          <day>15</day>
          <month>10</month>
          <year>2021</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Perspectives in Medical Research is committed to keeping research articles Open Access. Journal permits any users to read, download, copy, print, search, or link to the full texts of these articles, or use them for any other lawful purpose, without financial, legal, or technical barriers subject to proper attribution and ownership of the rights.</copyright-statement>
        <copyright-year>2021</copyright-year>
      </permissions>
      <abstract id="abstract-abstract-title-04cc1aa890d743f19141574ef9db71a5">
        <title id="abstract-title-04cc1aa890d743f19141574ef9db71a5">Abstract</title>
        <p id="paragraph-90344020709e458aa459517d5bd2230f"><bold id="s-25259e4a73a2">Introduction</bold>: Dexmedetomidine has been safely used as an adjuvant for subarachnoid block in obstetric as well as non-obstetric surgeries and was found to be effective without adverse effects. Hence, this study was conducted to determine the efficacy of intrathecal Dexmedetomidine for elective lower segment caesarean sections with reduction of local anesthetic dose.</p>
        <p id="paragraph-9a3cec8e9d4245ab9d1bfb82d94e7783"><bold id="s-013435855ac5">Objectives</bold>: This double blinded, randomized controlled study was designed to compare the effects of addition of Dexmedetomidine on 1) Sensory and motor block 2) Maternal hemodynamics 3) Post-operative analgesia and 4) Neonatal outcome.</p>
        <p id="paragraph-e70d6d97e7e844cba23a3a1e8d0021f9"><bold id="s-4afb7c06604a">Methods</bold>: Eighty parturients were enrolled in study and randomized into two groups as of 40 each and named as Group D and Group B. Group D received 0.5% Hyperbaric Bupivacaine 9mg (1.8ml) + Dexmedetomidine 5µg (0.2ml of 25 µg per ml ) and for Group B received 0.5% Hyperbaric Bupivacaine 10mg (2ml) . Characteristics of block, maternal hemodynamics and neonatal outcome were recorded. P value &lt;0.05 was considered as significant.</p>
        <p id="paragraph-914397605f8a44f48314a3ff406f9ff4"><bold id="s-87c5f79ff577">Results</bold>: Sensory onset was rapid in D group as compared to B group (3.7 ± 1.1vs 4.5±1.2) and motor onset was also rapid in D group (3.8±2.0 vs 4.9 ±1.9) with 95% CI. Duration of analgesia was also significantly high in Group D (230.5±40.5 vs 145.1±28.5). No adverse maternal and fetal outcomes were reported.</p>
        <p id="paragraph-b2a2972e74404a0798b7abf131d7555d"><bold id="s-7b0c40095f24">Conclusion</bold>: Intrathecal Dexmedetomidine with low dose bupivacaine for cesarean section hastens the sensory as well as motor onset without adversely affecting mother and neonate.</p>
      </abstract>
      <kwd-group id="kwd-group-0743f74682e2418d99725c8575cbe5c3">
        <title>Keywords</title>
        <kwd>Intrathecal Dexmedetomidine</kwd>
        <kwd>Cesarean section</kwd>
        <kwd>Low dose Bupivacaine.</kwd>
      </kwd-group>
      <funding-group>
        <funding-statement>Nil</funding-statement>
      </funding-group>
    </article-meta>
  </front>
</article>
