Introduction: Ultrasound and computed tomography-guided fine needle aspiration cytology play an important role in the diagnosis of deep-seated lesions such as intra-abdominal and intrathoracic diseases.

Objective: To evaluate the efficacy of ultrasound (USG) and computed tomography (CT)-guided FNAC in the diagnosis of abdominal and intrathoracic lesions for one year, from January 2021 to December 2021.

Materials And Methods: The study included 58 intraabdominal and 45 intrathoracic lesions. Cytological findings were correlated to clinical and radiographic data to arrive at a definitive diagnosis.

Results: Fine needle aspiration cytology was performed at various anatomical sites: liver (24 patients), colon (9 patients), gallbladder (5 patients), ovary (6 cases), spleen (3 cases), mesentery (3 cases), omentum ( 3 cases), cecum (2 cases), pancreas (1 case), subhepatic lesions (1 case), lung (43 cases), mediastinum (2 cases). The most common intra-abdominal disease was metastatic adenocarcinoma of the liver (14 patients), and the most common intrathoracic disease was lung adenocarcinoma (18 patients).

Conclusion: Ultrasound and computed tomography-guided fine needle cytology is an excellent method for deep diagnosis in the abdominal and thoracic cavity.