Prathima Institute of Medical Sciences Prathima Institute of Medical Sciences https://www.pimr.org.in/instructions.php Perspectives in Medical Research 2348-229X 2348-1447 0011 10.47799/pimr.1002.11 Original Article Comparison of Mammography, Sonography, Fine-Needle Aspiration Cytology, and Excision Biopsy for the Diagnosis of Breast Lesions Baig Rusab rusabbaig98@gmail.com 1 Desai Rajendra desai@live.in 2 Tabassum Mahenaaz 1 Mughni Mohammed Abdul 1 Quadri Syed Hamza 1 Rafai Syed Zainuddin 1 Department of General Surgery, Shadan Institute of Medical Sciences, MBBS Scholar, Shadan Institute of Medical Sciences Hyderabad Associate Professor,Department of General Surgery, Shadan Institute of Medical Sciences Hyderabad, Telangana India 30 8 2022 10 2 51 55 23 3 2022 5 5 2022 24 4 2022 Perspectives in Medical Research is committed to keeping research articles Open Access. Journal permits any users to read, download, copy, print, search, or link to the full texts of these articles, or use them for any other lawful purpose, without financial, legal, or technical barriers subject to proper attribution and ownership of the rights. 2022 Abstract

Background and Objective: Problem of invasive tests in breast lesion diagnosis can be addressed by comparing non-invasive tests with final Histopathological diagnosis obtained after excision biopsy. Present study was carried out to study diagnostic utility of mammography, sonography, FNAC compared to excision biopsy for diagnosis of breast lesions

Methods: Prospective Observational study was carried out among 81 women with Breast related symptoms. Digital Mammography Machine, ACUSON S3000™ Ultrasound System; FNAC and surgery for excision Biopsy were used. Sensitivity, Specificity, Accuracy, Positive and Negative Predictive values were measured and p<0.05 was considered as statistically significant.

Results: Sonography and FNAC composite have sensitivity, specificity, accuracy, positive and negative predictive values 100.00%, 81.40%, 90.12%, 82.61% and 100.00% respectively. Mammography+FNAC (97.3%) is not as sensitive as Sonography+FNAC (100%), Sonography combined with FNAC is equally sensitive to excision biopsy (100%) and therefore can be used for screening purpose.

Conclusion: Contrary to present guidelines which consider Mammography as most important screening tool for Breast Cancer, combination of Sonography and FNAC can be considered equally reliable.

 Keywords mammography sonography FNAC excision biopsy diagnosis breast lesions Nil