Prashanth Kumar M¹, Sukumar P²

^1,2Associate Professor, Department of Pathology, Prathima Institute of Medical Sciences,Karimnagar,Telangana.

Address for correspondence: Dr. Prashanth Kumar M, Associate Professor, Department of Pathology, Prathima Institute of Medical Sciences,Karimnagar,Telanagana,India

Email: prashanth.madoori90@gmail.com

Introduction: Malignant Mixed Mullerian Tumor (MMMT), also called as carcinosarcoma, is an aggressive rare variant of uterine malignancy. MMMT is commonly associated with post-menopausal, nulliparous females with hyperestrogenic states and with median age at presentation being 65 years. It is unusual for the tumor to be seen in pre-menopausal, multiparous female with no history of exogenous hormonal therapy. Less than 5% of the patients are younger than 50 years. MMMT’s are one such tumors which have not seen better treatment outcome owing to aggressive nature of the tumor and advanced stage of it and hence provide greater challenge to understand the tumor biology. This case report elucidates that factors other than hyperestrogenism should be considered to understand the mechanisms involved in genesis of such tumors possibly a denovo activation of stem cells and their differentiation into two different components.

Keywords :Malignant Mixed Mullerian tumor, uterus, multiparity, premenopausal age group