Satyaprabha Siripurapu ¹, Achanta Vivekanand², A Sarojini ³, Sethi Pruthwiraj ³

¹Assistant Professor, Department of Obstetrics and Gynecology, ² Professor, Department of Obstetrics and Gynecology, ³Associate Professor, Department of Obstetrics and Gynecology, Prathima Institute of Medical Sciences, Karimnagar, Telangana, India.

Address for correspondence: Dr. Satyaprabha Siripurapu, Assistant Professor, Department of Obstetrics and Gynecology, Prathima Institute of Medical Sciences, Karimnagar, Telangana, India.

Email: siripurapu.satyaprabha@gmail.com

Introduction: Oligohydramnios is defined as a single pocket of amniotic fluid measuring < 2 cm in both vertical and horizontal planes in the ultrasound or AFI < 5cm. Isolated oligo hydramnios refers to the absence of significant growth restriction, normalumbilical artery doppler velocimetry (absence of maternal and fetal risk factors) and failure to identifya recognizable underlying etiology. This study aims at determining the efficacy of maternal administration of amino acid infusion in improving the amniotic fluid volume in cases of isolated oligo hydramnios and observes its impact on the neonatal outcome.

Materials and Methods: A prospective study was conducted among women attending antenatal clinic of the Obstetrics and Gynecology department,Prathima Institute of Medical Sciences, Karimnagar from July 2014 to February 2015. The infusion was administered on alternate day along with 10% dextrose in between. The significance of changes in AFI was tested using paired t test and the relationbetween neonatal outcome was interpreted using an unpaired t test.

Results:The mean age of the participants in this study group was 23±2.54 years. The majority 42(51.2%) of the women were primigravida and 44 (53.7%) women were having a gestational age less than 34 weeks. The baseline AFI at the time of enrollment was 5.720 ± 1.0889 and there was Improvement in mean AFI score at the end of the first week (6.341±1.7265) second week (6.806 ± 1.7332) and third week (7.44 ± 1.593). The difference in the AFI scores were statistically significant (p=0.000). There was no statistically significant difference in weight of the baby, Apgar score at 5 minutes and admission in the NICU with AFI at the time of delivery (p=0.219, 0.332, 0.599 respectively).

Conclusion:Infusion of amino acids improved the AFI and its supplementation might be beneficial in The management of isolated oligo hydramnios.

Keywords :acid infusion, Isolated oligo hydramnios, Amniotic fluid index.