A study of pharmacokinetic interaction of Carbamazepine with Atorvastatin in dyslipidemic rats

Year : 2016 | Volume : 4 | Issue : 3 Page : 32 - 38

Dama Suresh¹, Raju Devde² ,Y. Narasimha Reddy³, Vasu Deva Rao⁴, Dr. Imran Khan⁵

^1,3Post Graduate, Department of Pharmacology, Kakatiya University, Warangal. ^2,4Associate Professor, ⁵Post graduate Student, Department of Pharmacology, Kakatiya Medical College, Warangal.

Address for correspondence: Dr. Raju Devde, Associate Professor, Department of Pharmacology, Kakatiya Medical College, Warangal, Telangana, Hyderabad. Phone No. 9989125124.

Email: rajudevde8@gmail.com

Abstract

Introduction: Every time a drug is administered with any other prescription medicine, OTC products, herbs or even food we expose ourselves to the risk of a potentially dangerous interaction.A drug interaction occurs when the pharmacological effects of the object drug alters the intensity of the precipitant drug. Whenever two or more drugs are taken concurrently there is a chance of an interaction among the drugs that could manifest as an increase or decrease in their effectiveness or an adverse reaction or a totally new side effect that is not seen with either drug alone.

Materials and Methods :The study was done on male Sprague dawley rats, divided into 5 groups each having at least six animals.The groups were initially treated with carbamazepine at different doses for two weeks. Then all the groups were administered orally with a dose of 10 mg/kg of atorvastatin.Blood was collected from retro orbital plexus at 0, 1, 2, 4, 6,8,10 and 12 h after oral administration of atorvastatin and then subjected for analysis.

Results:The influence of carbamazepine on the pharmacokinetics of atorvastatin is decrease in Cmax, bioavailability and T1/2 indyslipidemic rats.

Conclusion:From the present investigation it is shown that the carbamazepine having considerable inducing effect on atorvastatin. The decreased bioavailability of atorvastatin in the study might be attributed to the induction of CYP-3A4 by carbamazepine. It might be true that, concurrent administration of the atorvastatin and carbamazepine could lead to alternations in the concentrations of either drug as both of them are substrates for CYP-3A4.

Keywords:Carbamazepine, Atorvastatin, Male Sprague dawley rats, dyslipidemia.