advertise here

Original Articles

Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal

Year : 2017 | Volume : 5 | Issue : 3 Page : 29 - 32

Pullaiah Akinepalli 1, Narender Gaddam 2

1,2Assistant Professor, Department of Biochemistry, Kakatiya Medical College, Warangal,Telangana,India

Address for correspondence: Dr. Pullaiah Akinepalli, Assistant Professor,Department of Biochemistry, Kakatiya Medical College, Warangal, Telangana, India.



Introduction: Copper is an essential micronutrient and has an important role in foetal development. Disorders of Copper and Ceruloplasmin levels has been associated with pathological pregnancies.The determination of Copper:Ceruloplasmin ratio has been proposed as one of the better indicator of Copper status in pregnancy.

Objective: The present study was undertaken to assess the Copper status in healthy pregnant women of in and around warangal comparing with the age matched non-pregnant women without history of usage of oral contraceptives.

Materials and Methods The venous samples from twenty healthy pregnant women aged 20-40yrs in the third trimester as study group and from twenty healthy non-pregnant women as control group was taken to compare the levels of Serum Copper, Ceruloplasmin and Copper:Ceruloplasmin ratio between groups. Estimation of serum copper was done by End point colorimetric method, Ceruloplasmin by Immunoturbidometric assay on Auto analyzer and Copper:Ceruloplasmin ratio is calculated by formula.

Results : A statistically significant increase(p<0.05) in serum copper levels of pregnant women (41.64µmol/L ± 6.62) was noticed when compared with non-pregnant women (21.46 µmol/L ± 3.59). Serum ceruloplasmin levels of pregnant women (0.43 gm/L ± 0.07) was statistically significant increase compared with controls (0.21 gm/L ± 0.02) (p<0.05) and a decrease in Copper:Ceruloplasmin ratio of pregnant women (12.87 µmol/gm ± 1.51) when compared to control group (13.22 µmol/gm ± 1.6) was observed, not statistically significant.

Conclusion : Serum levels of Copper and Ceruloplasmin were significantly increased in pregnant women and Copper:Ceruloplasmin ratio decreased but not significant statistically.

Keywords : Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio, Pregnancy


Open Access

Perspectives in Medical Research is committed to keeping research articles Open Access.Journal permits any users to read, download, copy, print, search, or link to the full texts of these articles...
Read more