Perspectives in Medical Research

Volume: 5 Issue: 2

  • Open Access
  • Case Series

Kikuchi-Fujimoto disease: A study of Four cases

Abhijeet Ingle1, Vijaya Gattu2, Suhela R3

1Consultant Histopathologist , 2,3Consultant Pathologist, Yashoda Hospital, Malakpet, Nalgonda X- Roads, Hyderabad, Telangana, India.
Address for correspondence: Dr Abhijeet Ingle, Consultant Histopathologist, Yashoda Hospital, Malakpet, Nalgonda X- Roads, Hyderabad, Telangana, India.
Email: [email protected]

Year: 2017, Page: 62-64,

Abstract

Introduction: Kikuchi-Fujimoto disease (KFD) manifests in most cases as unilateral cervical lymphadenomegaly with or without accompanying fever. The disease is rare and mainly affects young women and has a self-limited course. KFD should be included in the differential diagnosis of suspected cases of viral infections, tuberculosis, reactive lymphadenitis, systemic lupus erythematosus and metastatic diseases. It can be histologically confused with lymphoma. The disease is benign and self-limiting and an excisional biopsy of an affected lymph node is often necessary for diagnosis. There is no specific therapy. This study reports four cases of female patients with KFD who were attended at Yashoda hospital, Malakpet. A review of the literature was carried out with a systematic search on this topic with the aim of informing physicians about this entity that is manifested by cervical masses and fever. Fourth case was interesting because of its association with autoimmune disease (SLE-systemic lupus erythematosus.).
 

Keywords: Kikuchi disease, histiocytic necrotizing lymphadenitis, lymphatic diseases, neck, lymph nodes.

References

1. Lazzareschi I, Barone G, Ruggiero A, et al. Paediatric Kikuchi-Fujimoto disease: a benign cause of fever and lymphadenopathy. Pediatr Blood Cancer. 2008;50(1):119- 23.
2. Paradela S, Lorenzo J, Martínez-Gómez W, Yebra-Pimentel T, Valbuena L, Fonseca E. Interface dermatitis in skin lesions of Kikuchi-Fujimoto's disease: a histopathological marker of evolution into systemic lupus erythematosus? Lupus. 2008;17(12):1127-35.
3. Park HS, Sung MJ, Park SE, Lim YT. Kikuchi-Fujimoto disease of 16 children in a single center of Korea. Pediatr Allergy Immunol. 2007;18(2):174-8.
4. Phelan E, Lang E, Gormley P, Lang J. Kikuchi-Fujimoto disease: a report of 3 cases.Ear Nose Throat J. 2007;86(7):412-3.
5. Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 2004;122(1):141-52.
6. Lerosey Y, Lecler-Scarcella V, Francois A, Guitrancourt JA. A pseudo-tumoral form of Kikuchi's disease in children: a case report and review of the literature. Int J Pediatr Otorhinolaryngol. 1998;45(1):1-6.
7. Norris AH, Krasinskas AM, Salhany KE, Gluckman SJ. Kikuchi-Fujimoto disease: a benign cause of fever and lymphadenopathy. Am J Med. 1996;101(4):401-5.
8. Miyashita Y, Yamaguchi M, Fujimoto W. Painful indurated erythema suggestive of Kikuchi-Fujimoto disease in a patient with primary Sjögren's syndrome. J Dermatol. 2003; 30(8):608-11.
9. Atwater AR, Longley BJ, Aughenbaugh WD. Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations. J Am Acad Dermatol. 2008;59(1):130-6.
10. Montejo M, Lekerika N, Astigarraga I, et al. Enfermedad de Kikuchi-Fujimoto: estudio decuatro casos [KikuchiFujimoto disease: review of four cases]. An Med Interna. 2006;23(4):1735.
11. Bosch X, Guilabert A. Kikuchi-Fujimoto disease. Orphanet J Rare Dis. 2006;1:18. Ifeacho S, Aung T, Akinsola M. Kikuchi-Fujimoto Disease: A case report and review of the literature. Cases J. 2008;1(1):187.
12. Melikoglu MA, Melikoglu M. The clinical importance of lymphadenopathy in systemic lupus erythematosus. Acta Reumatol Port. 2008;33(4):402-6.
13. Tanaka T, Ohmori M, Yasunaga S, et al. DNA typing of HLA class II genes (HLA-DR, -DQ and -DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi's disease). Tissue Antigens. 1999;54(3):246-53.
14. Stephan JL, Jeanoel P, Chanoz J,et al. Epstein-Barr virusassociated Kikuchi disease in two children. J Pediatr Hematol Oncol 2001;23:240-243.
15. Chiu CF, Chow KC, Lin TY,et al. Virus infection in patients with histiocytic necrotising lymphadenitis in Taiwan: detection of Epstein-Barr virus,type 1 human T-cell lymphotrophic virus and parvovirus B19.Am Clin Pathol 2000;113:774-781.
16. Yufu Y,Matsumoto M,Miyamura T,et al. Parvovirus B19- associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotising lymphadenitis (kikuchi's disease) .Br. J Haemtol 1997; 96:868-871
17. Kikuchi M, Ohshima K. Cervical lymphadenopathy , fever and leucopenia ( histiocytic necrotising lymphadenitis or kikuchis disease) Pathol Case Rev 2004; 9:199-205.
18. Ioachim's lymph node pathology ,4th edition. 200-201.

Cite this article

Ingle A, Gattu V, R Suhela. KikuchiFujimoto disease: Astudy of Four cases.Perspectives in Medical Research 2017;5(2):62-64.

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