Volume: 2 Issue: 1
Year: 2014, Page: 43-46,
Introduction: Phyllode tumours (PT) are fibroepithelial lesions that account for less than 1% of all breast neoplasms. With the non-operative management of fibroadenomas widely adopted, the importance of PT today lies in the need to differentiate them from other benign breast lesions. The study was done to study the spectrum of various stromal tumours of the breast and the age distribution of the cases affected.
Materials & Methods: A retrospective and prospective study was done on patients who were referred for lump in the breast. Cases were analyzed in detail regarding complete history, family history, clinical examination and other findings
Results: Stromal tumours of the breast were studied for a period of two years. Out of the total 19 cases, benign PT were 11 cases, borderline PT were 05 and one case each of malignant PT, leiomyoma and neurofibroma (NF) were diagnosed.
Conclusion: The present study highlights the spectrum of various stromal tumors of the breast like leiomyoma, neurofibroma and malignant PT. Complete excision of malignant PT should be done to avoid distant metastasis and the importance of fine needle aspiration cytology (FNAC) in early diagnosis of the tumour.
Keywords: Stromal tumours, Malignant phyllode, Leiomyoma, Neurofibroma of breast
1. Donegan WL. Sarcomas of the breast. In, Donegan WL, Spratt JS (edi). Cancer of the Breast. St. Louis, MO: Elsevier Science, Inc.,2002; 918-25.
2. Fiks A. Cystosarcoma phyllodes of the mammary gland--Müller's tumor. For the 180th birthday of Johannes Müller. Virchows Arch A Pathol Anat Histol. 1981;392(1):1-6.
3. Rowell MD, Perry RR, Hsiu JG, Barranco SC. Phyllodes tumors. Am J Surg 1993; 165: 376-9.
4. Hart WR, Bauer RC, Oberman HA. Cystosarcoma phyllodes. A clinicopathologic study of twenty-six hypercellular periductal stromal tumors of the breast. Am J Clin Pathol 1978; 70: 211-6.
5. Treves N, Sunderland DA. Cystosarcoma phyllodes of the breast: a malignant and a benign tumor; a clinicopathological study of seventyseven cases. Cancer 1951; 4: 1286-332.
6. Cohn-Cedermark G, Rutqvist LE, Rosendahl I, Silfverswärd C. Prognostic factors in cystosarcoma phyllodes.A clinicopathologic study of 77 patients. Cancer 1991;68:2017-22.
7. Noguchi S, Yokouchi H, Aihara T, Motomura K, Inaji H, Imaoka S, et al.Progression of fibroadenoma to phyllodes tumor demonstrated by clonal analysis.Cancer 1995;76:1779-85.
8. John R. Goldblum, Andrew L. Folpe, and Sharon W. Benign tumors of peripheral nerves. In, Weiss SW, Goldblum JR (eds). Enzinger and Weiss's Soft Tissue Tumours. 4th edition. St. Louis, Mosby, 2001;1111-1208.
9. Fletcher CDM. Peripheral neuroectodermal tumours. In, Fletcher CDM (eds). Diagnostic Histopathology of Tumours. 2nd edition. Edinburgh: Churchill Livingstone, 2000;1679- 1711.
10. Son EJ, Oh KK, Kim EK, Son HJ, Jung WH, Lee HD. Leiomyoma of the breast in a 50-year-old woman receiving tamoxifen. Amer J Roentgenol 1998; 171: 1684-6.
11. Reinfuss M1, MituśJ, Duda K, Stelmach A, Ryś J, Smolak K. The treatment and prognosis of patients with phyllodes tumor of the breast.An analysis of 170 cases.Cancer 1996;77:910-16.
12. Grimes MM, Cystosarcoma phyllodes of the breast:Histologic features,flow cytometry analysis and clinical correlations. Mod pathol 1992;5:232-39.
Shastry S, Mahesh Kumar U, Anandam G. Stromal tumours of the breast. Perspectives in medical research 2014; 2:43-46