Volume: 7 Issue: 3
Year: 2019, Page: 79-86,
Introduction: The incidence of coronary artery disease is on the rise in younger age groups due to early development atherosclerosis in coronary arteries. Coronary arteries tend to develop atheromatous plaques due to change in dynamics of blood flow which is greater in diastole as compared to systole when the plaques become unstable acute coronary syndromes like myocardial infarction occur.
Methods: This cross-sectional study was performed in Prathima Institute of Medical Sciences, Nagunur, Karimnagar for the patientsadmitted to ICCU.A total of n=50 patients with established acute myocardial infarction in the age group of < 40 years and age and sex-matched controls of similar numbers were used for comparison. Inclusion criteria were all the patients who have ischemic chest discomfort and are diagnosed as acute coronary syndrome based on electrocardiograph, serum biomarkers, and echocardiography.
Results: The mean age of the study group was 36.1 yrs. ranging from 25 - 40 yrs. The mean level of triglycerides in the study group was 177.6 mg/dl and the control group was 128 mg/dl.The mean total serum cholesterol of the study group was 206 mg/dl and that of control was 178mg/dl. There is a significant increase in the incidence of patients with increased LDL cholesterol in the study group as compared to the control group the values were also found to be significant. The mean level of HDL cholesterol in the study group was 39.4 mg/dl and the control group was 45 mg/dl. The lowest value of HDL cholesterol in the patients of the study group was 28 mg/dl and in the control group was 35 mg/dl.
Conclusion: the levels of serum Total Cholesterol, Low-Density Lipoprotein Cholesterol, Triglycerides are elevated in young AMI patients and the levels of High-Density Lipoprotein Cholesterol are decreased compared to matched controls.There is a significant incidence of risk factors like obesity, smoking, sedentary lifestyle, family history of coronary artery disease in the study population compared to matched controls. Therefore the presence of risk factors along with family history and existence of dyslipidemia must alert physicians regarding high chances of coronary artery diseases in young adults.
Keywords: Serum Lipid Profile, Young Adults, Ischemic Heart Disease
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Kamreddy P.A Study of Serum Lipid Profile in Young Adults with Ischemic Heart Disease. Perspectives in Medical Research 2019; 7(3): 79-86