Volume: 5 Issue: 3
Year: 2017, Page: 29-32,
Introduction: Copper is an essential micronutrient and has an important role in foetal development. Disorders of Copper and Ceruloplasmin levels has been associated with pathological pregnancies.The determination of Copper:Ceruloplasmin ratio has been proposed as one of the better indicator of Copper status in pregnancy.
Objective: The present study was undertaken to assess the Copper status in healthy pregnant women of in and around warangal comparing with the age matched non-pregnant women without history of usage of oral contraceptives.
Materials and Methods The venous samples from twenty healthy pregnant women aged 20-40yrs in the third trimester as study group and from twenty healthy non-pregnant women as control group was taken to compare the levels of Serum Copper, Ceruloplasmin and Copper:Ceruloplasmin ratio between groups. Estimation of serum copper was done by End point colorimetric method, Ceruloplasmin by Immunoturbidometric assay on Auto analyzer and Copper:Ceruloplasmin ratio is calculated by formula.
Results : A statistically significant increase(p<0.05) in serum copper levels of pregnant women (41.64µmol/L ± 6.62) was noticed when compared with non-pregnant women (21.46 µmol/L ± 3.59). Serum ceruloplasmin levels of pregnant women (0.43 gm/L ± 0.07) was statistically significant increase compared with controls (0.21 gm/L ± 0.02) (p<0.05) and a decrease in Copper:Ceruloplasmin ratio of pregnant women (12.87 µmol/gm ± 1.51) when compared to control group (13.22 µmol/gm ± 1.6) was observed, not statistically significant.
Conclusion : Serum levels of Copper and Ceruloplasmin were significantly increased in pregnant women and Copper:Ceruloplasmin ratio decreased but not significant statistically.
Keywords: Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio, Pregnancy
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Pullaiah A, Narender G. Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal. Perspectives in Medical Research 2017;5(3):29-32.