Volume: 4 Issue: 1
Year: 2016, Page: 14-18,
Introduction: Urticaria is a common pruritic skin disorder that affects 15 to 25% of individuals at some point of their life time. It is one of the most frustrating problem to the affected victim because it produces severe physical and emotional distress. Likewise, it poses a serious therapeutic dilemma to the attending dermatologist because of its chronicity and refractory nature of lesions to the treatment
Material and Methods:A total number of one hundred patients of either sex with history suggestive of chronic urticaria reporting to the out patient clinic of Dermatology, Venereology and Leprology (DVL) department during the period of two years from April 2009 to March 2011, constituted the subjects for the present study.
Results: The patients were in the age group of 11-65 years with maximum number (33%) being in the 21-30 years age group. Females (66%) outnumbered the males (34%) in the series. Majority of the patients (53%) belonged to the urban area and were literate (91%) . Duration of the disease varied from 6 weeks to 5 years and the most commonly observed was from 1-2 years. 58% of the patients had only Urticaria and the remaining 42% had Urticaria and angioedema
Conclusion: From the present study, it is concluded that the etiology is not clear in large number of patients and hence labelled as chronic idiopathic urticaria. Autologous serum skin test (ASST) constitutes one of the important screening test for autoimmune urticaria.
Keywords: Urticaria, Angioedema, Autoantibodies, Autologous serum skin test
1. Sheldon JM, Mathews KP, Lovell RG. The vexing urticaria problem; present concepts of etiology and management. J Allergy 1954; 25: 525-60.
2. Grattan CE, Sabroe RA, Greaves MW. Chronic urticaria. J Am Acad Dermatol 2002; 46:645–6O.
3. Asero R, Tedeschi A, Lorini M, Salimbeni R et al. Chronic urticaria: novel clinical and serological aspects. Clin Exp Allergy 2001; 31: 1105-10.
4. Kulthanan K, Jiamton S, Goravinch T et al. Autologous serum skin Test in Chronic Idiopathic Urticaria: Prevalence, Correlation and Clinical Implications. Asian Pacific Journal of Allergy and Immunology. 2006; 24:201-206.
5. Godse KV. Autologous serum skin test in chronic idiopathic urticaria. J Dermatol Venereol Leprol 2004; 70: 283-4.
6. George M, Balachandran C, Prabhu S. Chronic idiopathic urticaria: Comparison of clinical features with positive autologous serum skin test. Ind J Dermatol venereol Leprol 2008; 74: 105-8.
7. Krupashankar DS. Etiological approach to chronic urticaria. Ind J Dermatol 2010; 55(1): 33-8.
8. Champion RH, Roberts SO, Carpenter RG et al. Urticaria and angio-oedema. a review of 554 patients. Br J Dermatol 1969; 81:588-597.
9. Humphreys F, Hunter JAA. The characteristics of Urticaria in 390 patients . Br J Dermatol 1998; 138: 635-38.
10. Kikuchi Y, Kaplan AP. Mechanisms of autoimmune activation of basophils in chronic urticaria. J Allergy Clin Immunol 2002: 110: 492-9.
11. Sarojini PA, Gopinathan T, Mohandas PP. studies on 100 cases of urticaria with particular reference to the aetiology. Ind J Dermatol Venereol 1972; 38: 133-37.
Swetha, Rekha, Srikanth,Reddy. Clinico - etiological study of chronic Urticaria and the role of autologous serum skin test in the diagnosis of chronic idiopathic Urticaria. Perspectives in medical research 2016;4:1:14-18.