Volume: 6 Issue: 3
Year: 2018, Page: 45-48,
Introduction: Vitamin D deficiency is a pandemic, non communicable disease in India and worldwide. Vitamin D, which is technically a hormone rather than a fat soluble secosteroid responsible for increasing intestinal absorption of Calcium, Magnesium, Phosphate and multiple other biological effects. Researchers found that shift workers, indoor and healthcare workers are at an increased risk to develop Vit-D deficiency due to reduced outdoor time and sunlight exposure.
Aims and objectives: The rationale of this study was to find the Vit-D (1,25 OH2 Vit D) levels in apparently healthy medical students in Prathima Institute of Medical Sciences, Karimnagar.
Materials and Methods :The present study was done in General Medicine outpatient department, Vit-D levels were assessed in randomly selected 300 medical students with BMI of 18.5-24.9kg/m2, who had no past medical illness. 3ml of fasting venous sample from cubital vein was collected and analyzed for Vit-D levels by ADVIA -CENTAUR-XP automated analyzer by chemiluminescence immunoassay within 12 hrs.
Results :The total number of sample was 300 medical students, of which 160 were females and 140 were males. Among the girl students 77% (123) were Vit-D deficient and 21% (33) were having insufficiency. Among the Boys 66% (92) were deficient and 21% (30) were insufficient and 13% (18) were having normal Vit-D levels. Among the 300 medical students, 278 (92.7%) were having low vitamin D levels and only 22 (7.3%) were having normal Vitamin D levels.
Conclusion :A very high percentage of students were Vit-D deficient which correlates with higher incidence among health care workers. Limitations for the present study are it's a cross sectional study than longitudinal study. No validated questionnaire was used, analysis method used was not gold standard, needs study in a larger population group. However it is a safer practice to supplement all the students with Vitamin D supplements.
Keywords: 1, 25 (OH)2 Vit-D levels, Medical students, chemiluminescence method.
1). Suda T, Ueno Y, Fujii K, Shinki T. Vitamin D and bone. J Cell Biochem 2002;88:259-66.
2). Darwish HM, DeLuca HF. Identification of a transcription factor that binds to the promoter region of the human parathyroid hormone gene. Arch Biochem Biophys 1999;365:123-30.
3). Zella JB, DeLuca HF. Vitamin D and autoimmune diabetes. J Cell Biochem 2003;88:216-22.
4). Lemire JM, Ince A, Takashima M. 1,25-Dihydroxyvitamin D3 attenuates the expression of experimental murine lupus of MRL/1 mice. Autoimmunity 1992;12:143-8.
5). Cantorna MT, Munsick C, Bemiss C, Mahon BD. 1,25- Dihydroxycholecalciferol preventa and ameliorates symptoms of experimental murine inflammatory bowel disease. J Nutr 2000;130:2648-52.
6). Cantorna MT, Hayes CE, DeLuca HF. 1,25-Dihydroxyvitamin D3 prevents and ameliorates symptoms in two experimental model of human arthritis. J Nutr 1998;128:68-72.
7). Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study. Lancet. 2001;358:1500-1503. Doi:10.1016/S0140-6736(01)06580-1.
8). Zipitis C.S., Akobeng A.K. Vitamin D supplementation in early childhood and risk of type 1 diabetes: A systematic review and meta-analysis.Arch. Dis. Child. 2008;93:512- 517. Doi.10.1136/adc.2007.128579.
9). Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willet WC. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl.Cancer Inst. 2006;98:451-59. Doi: 10.1093/ jnci/djj101.
10). Ahn J, Peters U, Albanes D, Purdue MP, Abnet CC, Chatterjee N et al. Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team. Serum vitamin D concentration and prostate cancer risk: A nested casecontrol study. J Natl Cancer Inst 2008;100:796-804.
11). Ritu G, Gupta A. Vitamin D deficiency in India: Prevalence, causalities and interventions. Nutrients 2014;6:729-75.
12). Al-Elq A, Sadat-Ali M, Al-Turki H, Al-Mulhim F, Al-Ali AK. Is there a relationship between body mass index and vitamin D levels? Saudi Med J. 2009;12:1542-6.
13). Hollick MF, Chen TC. Vitamin D deficiency: A worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080s-6s.
14). Elsammak MY, Al-Wossaibi AA, Al-Howeish A, Alsaeed J. High prevalence of vitamin D deficiency in the sunny eastern region of Saudi Arabia: A hospital based study. East Mediterr Health J. 2011;17:317-22.
15). Hollick MF. High Prevalence of Vitamin D Inadequacy and Implications for Health. Mayo Clin Proc. 2006;81:353-73.
16). Gannage-Yared M, Chemali R, Yaacoub N, Halaby G. Hypovitaminosis D in sunny Country: Relation to Lifestyle and Bone Markers. J Bone Miner Res. 2000;15:1856-62.
17). Jones G, Horst R, Carter G, Makin HL. Contemporary diagnosis and treatment of vitamin D-related disorders. J Bone Miner Res. 2007;11(suppl 2):V11-5.
18). González-Padilla E, Soria López A, González- Rodríguez E, García-Santana S, Mirallave-Pescador A, Groba Marco Mdel V, et al. High prevalence of hypovitaminosis D in medical students in Gran Canaria, Canary Islands (Spain) Endocrinol Nutr.2011;58:267-73.
19). Multhani SK, Sarathi V, Shivane V, Bandgar TR, Menon PS, Shah NS. Study of bone mineral density in resident doctors working at a teaching hospital. J Postgrad Med. 2010;56:65-70.
20). Baidya A, Chowdhury S, Mukhopadhyay S, Ghosh S. profile of vitamin D in a cohort of physicians and daibetologists in Kolkata. Indian J. Endocrinol.Metab. 2012;16:S416- S417.
21). Valimaki VV, Alfthan H, Lehmuskallio E, Loyttyniemi E, Sahi T, Stenman UH, et al. Vitamin D status as a determinant of peak bone mass in young Finnish men. J Clin Endocrinol Metab. 2004;89:76-80.
22). Lips P, Hosking D, Lippuner K, Norquist JM, Wehren L, Maalouf G, et al. The prevalence of Vitamin D inadequacy among women with osteoporosis: A international epidemiological investigation. J Intern Med. 2006;260:245-54.
Karunakar Ch, Kasturi R R. Dilzith A K, Spandana T. Hypovitaminosis-D in medical students: Unrecognized or Undertreated. Perspectives in Medical Research 2018; 6(3):45-48.