Perspectives in Medical Research

Volume: 9 Issue: 2

  • Open Access
  • Original Article

Increased Notification of Tuberculosis Cases and MDR and XDR Cases Post Introduction of CBNAAT in Rajasthan: A Retrospective Case Study of 4 Years from 2015-2018

Neil Sharma1, Manish Kumar Singhal2, Rachna Agrawal3, Manoj Sharma4, Sona Goyal5

1. Assistant Professor, Department of Pathology GMC Bhartapur
2. Associate Professor, Department of Pathology, GMC Bhartapur
3. Assistant Professor, Department of Anatomy GMC Bhartapur
4. Assistant Professor, Department of Pathology , Mahatma Gandhi Medical college ,Jaipur
5. Consultant , Department of pathology , NIA ,Jaipur
Corresponding Author -  Dr Manish Kumar Singhal , Associate Professor, Department of Pathology, Government Medical College Bhartapur, address – A-157 Jawahar nagar Bharatpur 321001,
Email-ID: [email protected]

Year: 2021, Page: 38-42, Doi: https://doi.org/10.47799/pimr.0902.09

Received: Feb. 24, 2021 Accepted: May 3, 2021 Published: May 3, 2021

Abstract

Context: Tuberculosis is a major health problem in India .Accurate and also fast diagnosis of tuberculosis has remained a challenge and we determined the impact of CBNAAT on notification of tuberculosis cases in Rajasthan.
Aims: The Aim of the present Study was use of CBNAAT in tuberculosis and impact on rate of detection of TB and MDR and XDR TB in Rajasthan.
Methods and Material: We did a retrospective study of notified tuberculosis cases registered in government and private hospital from 2015 to 2018.comaprison was done for these 4 years
Results: There was a total increase of 57 percent over the period of 4 years from 2015 to 2018 in no of tuberculosis notified cases and during the same time there was a 51 percent and 66 percent increase in the number of MDR and XDR tuberculosis cases respectively.
Conclusion: Use of CBNAAT significantly increases the no of notified cases of tuberculosis along with MDR and XDR cases .as we recommend that it should be widely adopted and expanded.

Keywords: CBNNAT,MDR,XDR

References

1. World Health Organization. Global Tuberculosis Control: WHO Report 2010. (World Health Organization, 2010).
2. Wallis, R. S. et al. Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice. Lancet 375, 1920–1937 (2010).
3. Swaminathan, S. et al. Risk of development of tuberculosis in HIV-infected patients. Int. J. Tuberc.Lung Dis. 4, 839– 844 (2000).
4. Dewan, R., Anuradha, S., Khanna, A. & Garg, S. Role of cartridge-based nucleic acid amplification test (CBNAAT) for early diagnosis of pulmonary tuberculosis in HIV. J Indian Acad Clin (2015).
5. Helb, D. et al. Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology. J. Clin. Microbiol. 48, 229–237 (2010).
6. Boehme, C. C. et al. Rapid molecular detection of tuberculosis and rifampin resistance. N. Engl. J. Med. 363, 1005–1015 (2010).
7. Khedkar, D. T., Chitnis, U. B., Bhawalkar, J. S. & Mamulwar, M. S. Revised National Tuberculosis Control Program: Evolution, Achievements, and Challenges. Medical Journal of Dr. D.Y. Patil University 7, 5 (2014).
8. Hussain, D. M. H., Hussain, M. H., Quadri, M. A. A. & Prasad, C. E. ‘PREVALENCE OF TB IN PATIENTS WITH DM UNDER REVISED NATIONAL TUBERCULOSIS CONTROL PROGRAMME’. International Journal of Medical and Biomedical Studies vol. 3 (2019).
9. Raizada, N. et al. Catching the Missing Million: Experiences in Enhancing TB & DR-TB Detection by Providing Upfront Xpert MTB/RIF Testing for People Living with HIV in India. PLOS ONE vol. 10 e0116721 (2015).
10. Raizada, N. et al. Enhancing TB case detection: experience in offering upfront Xpert MTB/RIF testing to pediatric presumptive TB and DR TB cases for early rapid diagnosis of drug sensitive and drug resistant TB. PLoS One 9, e105346 (2014).
11. Steingart, K. R. et al. Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst. Rev. CD009593 (2014).
12. Dlamini-Mvelase, N. R., Werner, L., Phili, R., Cele, L. P. & Mlisana, K. P. Effects of introducing Xpert MTB/RIF test on multi-drug resistant tuberculosis diagnosis in KwaZuluNatal South Africa. BMC Infect. Dis. 14, 442 (2014).
13. Boyles, T. H. et al. False-positive Xpert® MTB/RIF assays in previously treated patients: need for caution in interpreting results. The International Journal of Tuberculosis and Lung Disease vol. 18 876–878 (2014).
14. Vassall, A. et al. Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a costeffectiveness analysis. PLoS Med. 8, e1001120 (2011).
15. Pai, M. Promoting affordable and quality tuberculosis testing in India. J. Lab. Physicians 5, 1–4 (2013).
16. Vassall, A. et al. Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a costeffectiveness analysis. PLoS Med. 8, e1001120 (2011).
17. Gerardo, A., Jose, M., Manoranjan, M. & Others. Rapid diagnosis of pulmonary and extra pulmonary TB in HIVinfected patients, comparison of LED flurescent microscopy and gene expert MTB/RIF assay in a district hospital in India. Tuberc. Res. Treat. (2012).
18. Sachdeva, K. S. et al. Use of Xpert MTB/RIF in Decentralized Public Health Settings and Its Effect on Pulmonary TB and DR-TB Case Finding in India. PLOS ONE vol. 10 e0126065 (2015).
19. Organization, W. H. & Others. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB. https://apps.who.int/iris/bitstream/handle/10665/ 112472/9789241506335_eng.pdf (2013).

Cite this article

Sharma N , Singhal M, Agrawal R, Sharma M, Goyal S. Increased Notification of Tuberculosis Cases and MDR and XDR Cases Post Introduction of CBNAAT in Rajasthan: A Retrospective Case Study of 4 Years from 2015- 2018. Perspectives in Medical Research 2021; 9 (2):38-42 DOI:10.47799/pimr.0902.09

Views
466
Downloads
149
Citations