Volume: 6 Issue: 2
Year: 2018, Page: 47-50,
Bakground: Hepatitis C virus (HCV) infection is a bloodborne infection, most commonly transmitted through sharing of needles (unsafe injection practices), blood and blood products whereas sexual and vertical routes of transmission are less common. HCV causes silent acute infection to severe chronic infection manifesting as chronic liver disease, fibrosis, cirrhosis, cancer, and liver failure. However chronic HCV infection-related complications can be prevented by early screening and treatment if required.
Objective : To evaluate the seroprevalence of HCV-specific antibodies in a hospital-based population.
Materials and Methods :The present hospital record-based, a cross sectional study was carried out at the rural based tertiary care center, in Northern Telangana, India, from January 2017 to July 2017. A total of 3748 blood samples were screened for HCV-specific antibody using 4th generation HCV TRI-DOT (Diagnostic Enterprises, H.P. India). The data of those, who were found to be reactive for HCV-specific antibodies were statistically analyzed by chi-square test, and results were considered significant if the p value was <0.05.
Results :Out of 3748 blood samples tested, 7 (0.19%) were found to be reactive for the HCV-specific antibody which includes 5 (0.23%) males and 2 (0.12%) females. The most commonly affected age group was less than 10 years.
Conclusion : In this study, the seroprevalence of HCV-specific antibody was 0.19%. This study highlights the current prevalence rate of HCV infection at our tertiary care center recommending mandatory screening of hospital attending population for early detection and prevention of chronic HCV infection related complications.
Keywords: Hepatitis C virus, HCV-specific antibody, hospital population, seroprevalence
1. WHO: Hepatitis C. Fact sheet No.164.World Health organization. (Updated July 2017) http://www.who.int/ mediacentre/factsheets/fs164/en/
2. Ananth Narayan, Paniker. Text Book of Microbiology, 10th Ed, Universities Press, India, 2017; pp 544-553.
3. Gowri, V., C. Chandraleka, R. Vanaja. The Current Seroprevalence of Hepatitis C Virus in a Tertiary Care Centre in Vellore, Tamil Nadu. Indian J. Community Med. 2012;37: 137.
4. Sood S, Malvankar S. Seroprevalence of Hepatitis B surface antigen, antibodies to the Hepatitis C virus, and human immunodeficiency virus in a hospital-based population in Jaipur, Rajasthan. Indian J Community Med 2010;35:165-9.
5. Parimal H. Patel, Hiral K. Patel, and Alka B. Nerurkar. Study of prevalence of Hepatitis C virus (HCV) infection in a patients attending tertiary care hospital Valsad, Gujarat, India. Int.J.Curr.Microbiol.App.Sci. 2017;6: 2783-2787. doi: https://doi.org/10.20546/ijcmas.2017.605.312.
6. Patil SR, Ghorpade MV, Patil SS, Shinde RV, Mohite ST. Seroprevalence of Antibodies to the Hepatitis C virus in a Hospital–Based Population: A study from western Maharashtra, India. International Journal of Collaborative Research on Internal Medicine & Public Health 2014;6:102-08.
7. B.Vallab Ganesh Bharadwaj, G.Vazhavandal, A.Uma and P.Chitra Rajalakshmi. Seroprevalence of Hepatitis C Virus Infection among Patients attending a rural teaching hospital in South India:A Three Year Study. Int. J. Curr. Microbiol. App. Sci. 2014;3:123-27.
8. Chakraborty A, Pramanik SB, Roy DS, Sarkar S, Chakraborty M, Nandi A. A retrospective study on the sero-prevalence of Hepatitis C infection in a Tertiary Care Hospital in Kolkata, India. Int J Curr Microbiol App Sci 2015;4:115-23.
9. Mishra S, Chayani N, Sarangi G, Mallick B, Pati SB. Seroprevalence of anti HCV antibody in and around Cuttack, Orissa. Indian J Med Microbiol 2002;20:40.
10. Khatoon R, Jahan N. Assessment of seroprevalence of hepatitis C virus-specific antibodies among patients attending hospital of semi-urban North India using rapid qualitative in vitro diagnostic test. Ann Trop Med Public Health [serial online] 2017 [cited 2017 Aug 5];10:199-204. Available from: http://www.atmph.org/text.asp?2017/10/ 1/199/205586
11. Sharma R, Sinha P, Bachiwal R, Rishi S. Seroprevalence of Anti hepatitis C virus antibodies in a hospital based population in Jaipur, Rajasthan. Indian J Community Med 2007;32:158-9.
12. Jahan N, Gupta V, Sana M, Mehrotra S, Khatoon R. Prevalence of anti-Hepatitis C virus antibodies among indoor patients and blood donors attending a tertiary care hospital in North India. Int J Res Med Sci 2016;4:4256-63.
13. Mindolli PB and Salmani MP. Seroprevalence of Hepatitis C Virus in a Tertiary Care Centre in Vijaypur, Karnataka, India. Int.J.Curr.Microbiol.App.Sci 2015;4: 956-959.
14. Sandhu R and Dahiya S. Prevalence of Anti-Hepatitis C Virus Antibodies among Inpatients and Outdoor Attendees of a Tertiary Care Institute. British Biomedical Bulletin 2015;3:008-014.
15. Bhattacharya S, Badrinath S, Hamide A, Sujatha S. Seroprevalence of hepatitis C virus in a hospital based general population in South India. Indian J Med Microbiol 2003;21:43-5.
16. Rajani M, Jais M. Age-wise seroprevalence of hepatitis C virus infection in clinically suspected infectious hepatitis patients attending a tertiary care hospital in Delhi. Int J Med Public Health 2014;4:78-81.
17. Schwarz TF, Dobler G, Gilch S, Jdger G. Hepatitis C and arboviral antibodies in the isolated population of Mauritius and Rodrigues. J Med Virol 1994;44:379-84.
18. Frommel D, Tekle-Haimanot R, Berhe N, Aussel L, Verdier M, Preux PM, et al. A survey of antibodies to hepatitis C virus in Ethiopia. Am J Trop Med Hyg 1993; 49:435-9.
19. Khan MS, Khalid M, Ayub N, Javed M. Seroprevalence and risk factors of Hepatitis C virus (HCV) in Mardan, NWFP: A hospital based study. Rawal Med J 2004; 29:57-60.
20. Ayele AG, Gebre Selassie S. Prevalence and risk factors of hepatitis B and hepatitis C virus infections among patients with chronic liver diseases in public hospitals in Addis Adaba, Ethiopia. ISRN Trop Med 2013; 1–7.
21. Singh B, Verma M, Verma K. Markers for transfusionassociated hepatitis in north Indian blood donors: Prevalence and trends. Jpn J Infect Dis 2004;57:49-51.
22. Nishioka S, Gyorkos TW. Tattoos as risk factors for transfusion-transmitted diseases. Int J Infect Dis 2001;5:27-34.
Palange P, Kandi V, Mohan Rao B. Seroprevalence of Hepatitis C virus-specific antibodies in a hospital based population attending tertiary care center: A study from Northern Telangana, India. Perspectives in Medical Research 2018;6(2):47-50.