Volume: 8 Issue: 2
Year: 2020, Page: 73-77, Doi: https://doi.org/10.47799/pimr.0802.16
Neonatal sepsis is one of the commonest causes of morbidity and mortality in neonates in India compared to the developed countries.
Aim: To evaluate the Procalcitonin level this is an early marker in the diagnosis of neonatal sepsis and to assess the suitability of this test in the diagnosis of early-onset sepsis.
Method: The prospective study was conducted in the Neonatal Division of Department of Pediatrics, Prathima Institute of Medical Sciences over a period of one year. The blood samples from 100 babies meeting the inclusion and exclusion criteria constituted the material for study.
Result: Among the n=100 cases n=39 were procalcitonin positive, compared with gestational age 10 (43.5%) cases were positive with a gestation of 37 weeks and there was no statistical significance concerning gestational age the association of material characteristics with procalcitonin positive and CRP positive levels. Blood culture was positive in n=9 (9%) of babies with (90% CI, 5.3-14.9) and negative in n=91 (91%) of babies with (90% CI, 85.2-94.7).
Conclusion: A positive blood culture is the only definitive and gold standard for confirming a case of sepsis. Since the culture and sensitivity test requires a minimum period of 48 hours which is a precious time in deciding on the treatment of sepsis in the newborn. Rapid diagnosis by using Procalcitonin and CRP gives a reasonable degree of accuracy in diagnosing neonatal sepsis and will also guide antibiotic therapy. Procalcitonin in comparison with CRP has better sensitivity and hence can detect most cases of neonatal sepsis and better negative predictive value.
Keywords: Procalcitonin, C Reactive Protein, Neonatal sepsis.
1. Zohra S. Lassi, Amara Majeed, Shafia Rashid, Mohammad Yawar Yakoob & Zulfiqar A. Bhutta The interconnections between maternal and newborn health – evidence and implications for policy, The Journal of Maternal-Fetal & Neonatal Medicine 2013;26:sup1:3-53.
2. Gizen Polat, Rustem AU, Elif Cadirci, Zekai Halici. Sepsis and Septic Shock: Current Treatment Strategies and New Approaches. Eurasian J Med 2017; 49(1): 53–58.
3. U K Mishra, SE Jacobs, LW Doyle, SM Garland. Newer approaches to the diagnosis of early-onset neonatal sepsis. Arch Dis Child Fetal Neonatal Ed 2006; 91(3): F208– F212.
4. Elizabeth Mathai, Usha Christopher, Matthews, Mathai, Atanu Kumar Jana, Dolly Rose, Staffan Bergstorm. Is Creactive protein level useful in differentiating infected from uninfected neonates among those at risk of infection? Indian Pediatr 2004; 41: 895-900.
5. Tallur SS, Kasturi AV, Shobha D Nadgir, Krishna BVS. Clinicobacteriological Study of neonatal septicemia in Hubli. Indian J Pediatr 2000; 67(3): 169-174.
6. Abida Malik, Shoaib E. Hasani, Harris M. Khan, Azra J. Ahmed. Nosocomial infections in newborn. Indian Pediatr 2001; 38: 68-71.
7. Kurien Anil Kuruvilla, Swati Pillai, Mary Jesudason, Atanu Kumar Jana. Bacterial Profile of Sepsis in a Neonatal unit in South India. Indian Pediatr 1998; 35: 851-858.
8. Raghavan M, Mondal GP, Bhatt V, Srinivasan S. Perinatal risk factors in neonatal infections. Indian J Pediatr 1992; 59; 335-440.
9. Betty Chacko, Inderpreet Sohi. Early Onset of Neonatal Sepsis. Indian J Pediatr 2005; 72: 23-26.
10. Rodwell RL, Anton LL, David IT. Early diagnosis of Neonatal sepsis using a hematological scoring system. J Pediatr 1987; 112: 761-67.
11. Boyle RJ et al. Early identification of sepsis in Infants with Respiratory distress. Pediatrics 1978; 62: 744-750.
12. Emine Kocabas, Aysun Sarikcioglu, Necmi Aksaray, Gulsah Seydaoglu, Yalcin Seyhun, Akgun Yaman. Role of Procalcitonin, C reactive Protein, IL1, IL6, IL8 and Tumour necrosis in diagnosis of neonatal sepsis. Turk J Pediatr 2007; 49: 1-10.
13. Naher BS, Mannan MA, Noor K, Shahiddullah M. Role of serum procalcitonin and C-Reactive Protein in the diagnosis of neonatal sepsis Bangladesh Med Res Counc Bull 2011; 37: 40-46.
14. Yadolla Zahed Pasha, Mousa Ahmadpour-Kacho, Mohmud Hajiahmadi, Mohsen Haghshenas. Iran J Pediatr Jun 2009; 19 (2):117-122
Neelagiri Udaya Kumar. Serum Procalcitonin and C Reactive Protein in as early markers neonatal sepsis- A prospective study. Perspectives in Medical Research 2020; 8 (2):73-77. DOI : 10.47799/pimr.0802.16