Volume: 3 Issue: 3
Year: 2015, Page: 27-29,
Objective: Conjunctival squamous cell carcinoma is a cancer on the surface of the eye. It usually arises at the limbus as papillary exophytic grey-white mass. Histologically, squamous carcinomas which arise in the conjunctival epithelium are well differentiated tumors. Squamous cell carcinoma is locally invasive but rarely spreads to distant sites. Squamous cell carcinomas of conjunctiva are rare tumours which occur in the sun damaged ocular surface, usually at the limbus. Metastasis of squamous cell carcinoma of conjunctiva is also rare. In this case sclera and corneal invasion was noted but ciliary body and other structures were not involved.
Keywords: Ocular surface squamous neoplasia, squamous cell carcinoma, conjunctiva, keratin pearls, invasion.
1. Lee GA, Hirst LW .Incidence of ocular surface dysplasia in metropolitan Brisbane.Arch Ophthalmol 1992;110:525– 527.
2. H. E. Grossniklaus, W. R. Green, M. Luckenbach, and C. C.Chan, “Conjunctival lesions in adults. A clinical and histopathologic review,” Cornea, 1987;6(2): pp. 78–116.
3. Gamel JW, Eiferman RA, Guibor P. Mucoepidermoid carcinoma of the conjunctiva. Arch Ophthalmol 1984; 102: 730-1.
4. Peksayar G, Altan-Yaycioglu R, Onal S. Excision and cryosurgery in the treatment of conjunctival malignant epithelial tumours. Eye. 2003 Mar;17(2):228-32.
5. Lee GA, Williams G, Hirst LW, et al.Risk factors in the development of ocular surface epithelial dysplasia. Ophthalmology.1994; 101:360–364.
6. Goldberg SH, Riedy DK, Lanzillo JH Invasive squamous cell carcinoma of the palpebral conjunctiva. Graefes Arch Clin Exp Ophthalmol.1993; 231:246–248.
7. McKelvie PA, Daniell M, McNab A, Loughnan M, Santamaria JD. Squamous cell carcinoma of the conjunctiva: a series of 26 cases. Br J Ophthalmol 2002;86:168– 7Sen S, Sharma A, Panda A. Immunohistochemical localization of human papilloma virus in conjunctival neoplasias: a retrospective study. 1. Indian J Ophthalmol. 2007;55:361–3.
8 Lauer SA, Malter JS, Meier R.Human papillomavirus type18 in conjunctival intraepithelial neoplasia. Am J Ophthalmol .1990;110:23–27
9. McDonnell JM, McDonnell PJ, Sun YY ,Human papillomavirus DNA in tissues and ocular surface swabs of patients with conjunctival epithelial neoplasia. Invest Ophthalmol Vis Sci,1992;33:184–189.
10. Margo CE, Mack W, Guffey JM.Squamous cell carcinoma of the conjunctiva and human immunodeficiency virus infection. Arch Ophthalmol.1996;114:349
11. Saegusa M, Takano Y, Hashimura M, et al. HPV type-16 in conjunctival and junctional papilloma, dysplasia, and squamous cell carcinoma. Pathol J Clin.1995;48:1106– 1110
13. Glasson WJ, Hirst LW, Axelsen RA, et al.Invasive squamous cell carcinoma of the conjunctiva. Arch Ophthalmol.1994;112:1342–1345.
14. Iliff WJ, Marback R, Green R .Invasive squamous cell carcinoma of the conjunctiva. Arch Ophthalmol.1975;93:119–112.
15. G.Cervantes, A. A. Rodr´iguez Jr, and A. G. Leal, “Squamouscell carcinoma of the conjunctiva: clinicopathological features in 287 cases,” Canadian Journal of Ophthalmology.2002; 37(1):14–20.
16. Cha SB, Shields JA, Shields CL, et al.Squamous cell carcinoma of the conjunctiva. Int J Ophthalmol Clin.1993;33:19–24.
Padmaja B.V.N, Anandam G, Sharadrutha, Mahesh Kumar U,Srikanth S,Ramman Kumar Ch. Squamous cell carcinoma of Conjunctiva. Perspectives in medical research 2015;3:3:27-29.